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Eur J Pharmacol 2005;516:131-8

These criteria greatly limit the universe of potential respondents

[ X ] out is the concentration of the ionic species X in the extracellular fluid

Clinical evidence consistently demonstrates that vitamin C bioavailability is the decisive factor determining physiological impact

In this context, ferroptosis exerts a context-dependent double-edged sword effect [127]: while targeted induction of ferroptosis in hyperproliferative PASMCs could theoretically reverse remodeling, uncontrolled ferroptosis leads to deleterious vascular injury [128, 129]

374 New potential pharmacological targets The abovementioned antidepressants have been utilized as clinical therapies for MDD, but it is difficult to elucidate the exact pharmacological mechanisms of every medicine due to delayed clinical efficacy, poor treatment response to some patients, and difficulty in effectively controlling the incidence of suicide