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Additional Supportive Data ALPINE Trial: Study Design A phase 3b, multicenter, randomized, double-blind, active-controlled study evaluating the efficacy and safety of ARISTADA INITIO (aripiprazole lauroxil) and the ARISTADA (aripiprazole lauroxil) 2-month dose (1064 mg) or paliperidone palmitate monthly 1 The objective of ALPINE (Aripiprazole Lauroxil and Paliperidone palmitate: INitiation Effectiveness) was to evaluate the efficacy and tolerability of the single-day ARISTADA Initiation Regimen utilizing the ARISTADA 1064 mg 2-month dosing option during the first 4 weeks of treatment in adult patients hospitalized for an acute exacerbation of schizophrenia

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Manifestations of glutathione synthetase deficiency usually include hemolytic anemia, often include metabolic acidosis, and sometimes include progressive neurologic symptoms as well as other systemic signs

One possible explanation is that hyperoxidized PRXs in the SRX mutant could either signal as damage associated molecular patterns (DAMPs) themselves or alter post-translation modifications of other proteins that in turn signal as DAMPs, to induce beneficial response pathways 53