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3-NP is also involved in the activation of microglia and promotes the release of inflammatory cytokines that lead to neurological dysfunction and striatal neuronal death (Kim et al
Mateo-Gallego, R
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519 DPI disrupts mitochondrial respiration, NOS, and other complexes, causing off-target superoxide bursts, while VAS3947 induces apoptosis via cysteine thiol alkylation, independent of NOX activity
, Dash, K
