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Studies have indicated that flavonoids regulate immune cell functioning through multi-target and multi-pathway mechanisms, exhibiting broad anti-inflammatory and immunomodulatory properties across various inflammatory conditions

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This interaction creates a positive feedback loop where M2 macrophages, in turn, further enhance CSC survival, resistance to therapy, and tumor aggressiveness, making the CSCTAM crosstalk a significant target for potential therapeutic strategies (127)

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In addition, MTs overexpression exerts a positive effect on alleviating diabetes and diabetic cardiovascular complications through attenuating oxidative stress [11,44,45], whereas another study indicated a negative correlation between MT-1 overexpression and insulin secretion [46]

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