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Neurotrophins promote neural survival while substantial decreases in their levels have been measure in several neurodegenerative diseases

Luo et al., 2023)] may trigger a systemic-central inflammatory cascade via the gut-brain axis (Lim, 2018) The overproduction of ROS by microglia is hypothesized to be a pivotal mediator in this process, inducing an increase in NLRP3 inflammasome-mediated IL-1 elevation within the POA (Zhang Z

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Biochem J 417:287296

Swanink CM, Melchers WJ, van der Meer JW et al