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Alpers-Huttenlocher Syndrome) and children under two years of age who are suspected of having a POLG-related disorder (see Hepatotoxicity/Hepatic dysfunction under Precautions)

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This pathway is the primary energy source for the heart and a major energy source for skeletal muscle during sustained activity

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In addition, although our SGB model can fit the EU-NN database well with less overfitting (i.e., it shows good performance in the testing set), the generalization of our model to other narcolepsy databases such as the ones from the United States of America and China is unknown