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After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return
J Immunol 201:13431351 Singh RP, Grinenko T, Ramasz B et al (2018) Hematopoietic stem cells but not multipotent progenitors drive erythropoiesis during chronic erythroid stress in EPO transgenic mice

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Furthermore, there have been significant advances in determining the role of both the innate immune system and genetic factors that might predispose individuals to APAP-mediated toxicity

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