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Therefore, above we considered how TLR4 potentially can trigger LPS-induced inflammation caused by the disruption of intestinal integrity through the TIRAP/MyD88 signaling cascade, that leads to the early activation of NF-B (Figure 2, left part)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Xu H., Hao Q., Liu H., Chen L., Wu R., Qin L., Guo H., Li J., Yang C., Hu H., Xue K., Feng J., Zhou Y., Liu B., Li G., Wang X

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J Pathol (2011) 224:40110

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