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doi:10.1021/jm020017n CrossRef Escamilla S, Sez-Valero J, Cuchillo-Ibez I

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Hyperpolarized 13 C MRS provides an alternate, rapid approach to measure metabolic fluxes in vivo and, in the context of the PPP, hyperpolarized [U- 13 C, U- 2 H]glucose has been shown to be useful to monitor flux to 6PG in vivo (5052)

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While clinical applicability remains to be fully established, the mechanistic insights presented here support the hypothesis that melatonin holds promise as a potential adjunctive agent in age-related neurological disease management