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Description
Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL
DomazetovicVMarcucciGFalsettiIBiliaARVincenziniMTBrandiMLet al
Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)
Therefore, the lack of an adaptation period may have influenced the findings
The serine de novo synthesis pathway (SSP) represents a pivotal metabolic bypass of glycolytic metabolism, whereby the glycolytic intermediate 3-phosphoglyceric acid is converted into serine and glycine through the action of numerous metabolic enzymes, including phosphoglycerate dehydrogenase (PHGDH)
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