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However, our data demonstrate that non-discriminately disrupting glycolysis in infected and uninfected erythrocytes neither drives antiparasitic activity nor improves the outcome of acute malaria infection

Studler et al., 2005

Indeed, due to the vitreal-aqueous gradient, changes in the retinal secretome may reflect alterations in composition of AH, which is increasingly being used for proteomic and metabolomic analysis of retinal diseases, including glaucoma 9,13,14,15

Low oral bioavailability and rapid systemic clearance in rats further complicate its toxicological assessment

It was proposed by Aslund and colleagues that the oxidation of OxyR in Escherichia coli is constitutive in certain strain backgrounds, even in the absence of added oxidants, since the oxidation and activity of OxyR was elevated in mutants of the Trx and Grx systems