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One prominent change induced by chemotherapeutic agents involves the disruption of neuronal cytoskeletal architecture and axonal transport dynamics largely influenced by the interference of microtubule stability in peripheral neurons
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Unlike melanoma that spreads superficially, LMM is more closely linked to history of skin cancer and prior lentigines and is not linked to preexisting nevi or the likelihood of developing nevi [8]

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Am J Physiol Regul Integr Comp Physiol 282:R1227R1235 [DOI] [PubMed] [Google Scholar] Sartin JL, Wagner CG, Marks DL, Daniel JA, McMahon CD, Obese FY, Partridge C 2005 Melanocortin-4 receptor in sheep: a potential site for therapeutic intervention in disease models