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Ovarian function suppression with luteinizing hormone-releasing hormone agonists for the treatment of hormone receptor-positive early breast cancer in premenopausal women

An important advantage of this therapy is that it does not significantly increase hormones such as cortisol or prolactin, which are often associated with unwanted side effects

Chronic hyperprolactinemia evoked by disruption of lactotrope dopamine D2 receptors impacts on liver and adipocyte genes related to glucose and insulin balance

Notably, the observed downregulation of Metallothionein-2 (Mt2) in the serum proteome results, a well-established inducible antioxidant and metal-chelating protein in serum, strongly supports the interpretation of reduced oxidative stress