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The role that NAC may have in restoring normal levels of the inflammatory response is the result of a close interrelation between oxidative stress and inflammation, in whose response several mediators contribute, such as IL-1, IL-6, IL-10, TNF-, and NF-B, which mediate the redox-dependent regulation of inflammatory cytokines [4]

[DOI] [PubMed] [Google Scholar] 113.Banji D., Banji O.J., Abbagoni S., Hayath M.S., Kambam S., Chiluka V.L

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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[DOI] [PubMed] [Google Scholar] 38.Ge L., Yang M., Yang N.-N., Yin X.-X., Song W.-G