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Age-specific changes in brain GSH levels were assessed cross-sectionally using MRS in the living brain and/or biochemical assays in autopsy tissue in 10 unique ROIs, of which six (occipital, precuneal, posterior cingulate, anterior cingulate (medial pregenual), medial frontal and prefrontal dorsolateral regions) had been investigated by reproducibility studies with reliable GSH measures demonstrated

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[DOI] [PubMed] [Google Scholar] Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S

272 Of note, the prognostic value of the vitamin B6 metabolism among NSCLC patients was clear when PDXK levels were quantified by immunohistochemistry (IHC) in malignant cells, but neither when the adjacent, non-malignant lung tissue was analyzed (implying that the effect of vitamin B6 on disease progression originates in the tumor) nor when the amount of the PDXK-coding mRNA was assessed in tumor biopsies (perhaps suggesting that PDXK is subjected to a relevant degree of post-transcriptional regulation)