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At t = 0s, the muscle was stimulated via supramaximal pulses of 1 ms duration and 125 Hz frequency

4.2 Oxidative stress and mitochondrial dysfunction Renal energy metabolism depends heavily on oxidative phosphorylation, and in CKD, mitochondrial dysfunction and oxidative stress form a vicious cycle that exacerbates tissue injury

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Resistance to 5-FU has been associated with increased dependence on L-serine, either through SSP upregulation or enhanced serine uptake

Non-canonical independent defense systems In addition to the canonical GPX4/GSH axis, cells possess other parallel, GPX4-independent anti-ferroptotic pathways that provide additional layers of protection

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