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Bejarano, L., Jordo, M

9,10 Mitochondria, which are critical for cellular respiration and metabolism, suffer damage to their own mitochondrial DNA by the actions of reactive oxygen species and peroxynitrite compounds, and they have been directly implicated in the process leading to cessation of ATP synthesis

doi: 10.15698/mic2020.01.702 192 ZavrelM.WhiteT

Significance of brain glucose hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases

Limited effectiveness in moderate-to-severe UC: Many patients eventually require escalation to stronger therapy