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The most common adverse reactions in patients with sickle cell disease or other anemias (incidence 6%) are pyrexia, abdominal pain, bone pain, headache, vomiting, pain in extremity, sickle cell anemia with crisis, back pain, ALT increased, AST increased, arthralgia, oropharyngeal pain, nasopharyngitis, neutrophil count decreased, cough and nausea

2017;357:j1957

Colthup, P

When it might be considered (conceptually): A patient has clear metabolic disease, is doing the basics well, and theres a specific reason to pursue an adjunct rather than optimizing the primary plan

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10.1093/jxb/ern252 J