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One region is termed as G-site, which is hydrophilic in nature and binds the physiological substrate GSH, and another region is the H-site, which assists in binding of electrophilic substrates by providing a hydrophobic environment (Frova, 2003)

PMID: 173 LindaS

172,173 In support of these findings, in vivo studies using mouse stroke models have demonstrated that ATX knockout reduces LPA levels, improves vascular permeability, enhances cerebral blood flow, and decreases infarct volume, collectively reducing HCM-associated vascular dysfunction