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Description
Most data comes from animal studies, a few human special-case studies, and anecdotal evidence

Rao JS, Harry GJ, Rapoport SI, Kim HW

In patients with diabetes, glucose fluctuations were more strongly correlated with increased oxidative stress than chronic hyperglycemia, suggesting that wide variations in glucose levels may be a more important risk factor for AF (34)
Risk factors for both acute and recurrent HZO include immunocompromised status, female sex, autoimmune disorders, and an age of 50 years or older

However, synthetic materials may lack the specific biological signals and microenvironments present in natural materials that are crucial for cell behavior and tissue regeneration

IL-4 and SDF-1 increase adipose tissue-derived stromal cell ability to improve rat skeletal muscle regeneration
