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Description
Cognitive Enhancement Studies Cognitive improvement studies in 28-month-old mice (equivalent to elderly humans) using 10 mg/kg body weight administered 5x per week for 3 weeks demonstrated: Significantly faster escape hole finding in Box Maze tests (trials 4 and 5) Evidence of decreased brain inflammation Increased histone deacetylase 2 labeling indicating epigenetic pathway activation Preliminary reversal of age-related cognitive impairment Pain and Anxiety Modulation Anti-pain effects in mice at 0.5 mg/kg showed efficacy comparable to cimetidines human analgesic effects, affecting 7 anti-pain genes (increased) and 2 genes (decreased), with upregulated opioid receptors and related pain-modulating pathways
Conclusion: Support Your Gut, Do Not Fight It GLP-1 medications do far more than suppress appetite
From Week 6 onward, the p-values showed no significant difference between groups

[DOI] [PubMed] [Google Scholar] Dorlet P

The same group went on to determine the signaling pathway downstream of RAC1 that was regulated by DISC1

