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The reciprocal mutation (Gln to Glu) on MhTyrA p reduced PDH activity while gaining ADH activity (Figure 4, Table 1), further supporting that the corresponding 222 position in microbial TyrA enzymes is also important for their substrate specificity

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Liu, T., Gou, L., Yan, S

American Journal Of Clinical Dermatology, 14 (2), 147-153