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mGSH is also the primary defense against oxidative damage to mitochondrial membranes by ensuring the reduction of hydroperoxide groups on phospholipids and other lipid peroxides through the actions of mitochondrial GSH-S-transferases (GSTs), that exhibit modest Se-independent Gpx activity, and of Gpx4, a membrane-associated enzyme that is partly localized to the intermembrane space of the mitochondria (19, 109, 129)

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