aod9604 does not increase igf1 human study PDF] Safety and Tolerability of the Hexadecapeptide in Humans Mechanisms of Disease: metabolic effects
Description
In the Phase 2b trial (2007, n=536) AOD-9604 showed weight reduction only 0.3 kg greater than placebo after 24 weeks
![aod9604 does not increase igf1 human study PDF] Safety and Tolerability of the Hexadecapeptide in Humans Mechanisms of Disease: metabolic effects](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fncpendmet0427/MediaObjects/41574_2007_Article_BFncpendmet0427_Fig1_HTML.jpg)
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Some people may experience: Soreness at the injection site: A little redness or swelling where the injection was given
Unlike GLP-1 agonists that reduce appetite or growth hormone peptides that stimulate lipolysis, the compound addresses fat metabolism at the enzymatic level: it removes the molecular governor that locks adipocytes into a low-energy-expenditure state, potentially restoring normal metabolic function in fat tissue where NNMT is overexpressed
![aod9604 does not increase igf1 human study PDF] Safety and Tolerability of the Hexadecapeptide in Humans Mechanisms of Disease: metabolic effects](https://edrubinmd.com/images/blog/peptide-weight-loss-aod9604-motsc-tesamorelin-semaglutide-tirzepatide.png)
Second, the only way to ensure proper uptake is by taking the most bioactive form of the vitamin
![aod9604 does not increase igf1 human study PDF] Safety and Tolerability of the Hexadecapeptide in Humans Mechanisms of Disease: metabolic effects](https://honestpeptide.com/wp-content/uploads/2025/09/AOD-9604-Chemical-Structure.webp)
When you take enough B12, your metabolism gets an extra boost
![aod9604 does not increase igf1 human study PDF] Safety and Tolerability of the Hexadecapeptide in Humans Mechanisms of Disease: metabolic effects](https://peptidepowereu.is/wp-content/uploads/2026/06/aod-9604-profile-scaled.jpg)