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(ii) rats self-administer acetaldehyde into the brain ventral tegmental area (VTA), at concentrations that are three orders of magnitude lower than those required for ethanol to induce its self-administration (Rodd et al., 2005)

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BPC-157 works through VEGFR2-Akt-eNOS signaling and nitric oxide production

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Under basal conditions, NRF2 is bound by Keap1 and targeted for degradation [57, 58]

Dysbiosis can lead to the activation of pro-inflammatory pathways, such as the NF-B pathway, which in turn increases the production of cytokines and inflammatory mediators that compromise the BBB (Sanz and De Palma, 2009)