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When a drug binds extensively to components outside the plasma, such as proteins in muscle or lipids in adipose tissue, only a small fraction of the total drug in the body remains in the plasma to be measured

found that dysregulation of system enhances Treg function that promotes VEGF blockade resistance in glioblastoma (45)

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[DOI] [PubMed] [Google Scholar] 80.Curhan S.G., Eavey R., Wang M., Stampfer M.J., Curhan G.C

Kavanagh KT, Hafer LJ, Kim DW, Mann KK, Sherr DH, Rogers AE, Sonenshein GE: Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture

Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA et al (2018) Sjgren-like lacrimal keratoconjunctivitis in germ-free mice