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The enhancement of PDHC acetylation through ACAT1 activation helps recruit PDK to the phosphorylation sites of PDH, thus inducing a decrease in PDHC activity, while the blockade of PDHC acetylation through SIRT3 activation may lead to its dephosphorylation and activation (31)

If the medication is necessary during breastfeeding, breastfeeding should be discontinued

The inner domain mediates formation of the core complex with E3BP and contains the acetyltransferase catalytic activity

Microsc Res Tech 88:18691880

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Numerous preclinical studies have confirmed that Nrf2 activation protects against hepatocyte apoptosis, inflammation, and fibrosis, delaying the onset of cirrhosis and early tumorigenesis [30, 31]