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The acute COVID-19 group showed clearly a distinct metabolome profile from the other three groups

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Annu Rev Pharmacol Toxicol 44:32547, PMID: 14744249 Holmgren A, Lu J (2010) Thioredoxin and thioredoxin reductase: current research with special reference to human disease

Mechanisms such as inflammation, oxidative stress, vascular dysfunction, and metabolic dysregulation are central to this comorbidity