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Clinical evidence of inflammation driving secondary brain injury: a systematic review

Furthermore, imbalances in other neurotransmitter systemssuch as excessive glutamatergic activity and reduced GABA-mediated inhibitioncontribute to the diversity and severity of symptoms observed in PD

doi: 10.1152/physrev.00062.2017 10 DiNuzzoM.MangiaS.MoraschiM.MascaliD.HagbergG

doi: 10.1016/j.jacbts.2020.03.015

It should be noted that in vitro IC 50 concentrations may not directly reflect clinically achievable plasma or tissue levels, and translational interpretation requires pharmacokinetic validation