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In early studies, selective knockout of the GPX4 gene in hippocampal neurons promotes neurodegeneration and cell death in a non-apoptotic manner, which provide preliminary evidence for GPX4 as a particular regulator of ferroptosis (Seiler et al., 2008)

Moreover, oxidative stress upregulates adhesion molecules like intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on orbital fibroblasts and endothelial cells, facilitating immune cell recruitment and adhesion to inflamed orbital tissue (88, 89)

Fractions for AEA and 2-AG measurement were obtained by eluting the columns with 9:1 (by volume) chloroform/methanol and then analszed by LCAPCIMS

Fernandez-Twinn, D

The equilibrium ratio of thiol to thiolate forms varies with pH and is characteristic for specific thiol groups located within a distinct protein environment

CD44 is a potential immunotherapeutic target and affects macrophage infiltration leading to poor prognosis