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Abbreviations AF: Annulus fibrosus ASC: Adipose-derived stem cell BMP-2: Bone morphogenetic protein-2 BMSC: Bone marrow-derived stem cell CD: Chondrodystrophic CLC: Chondrocyte-like cell CTGF: Connective tissue growth factor DH: Disc height ECM: Extracellular matrix EP: End plate GAG: Glycosaminoglycan GDF-5: Growth and differentiation factor-5 IGF-1: Isulin-like growth factor-1 IVD: Intervertebral disc MSC: Mesenchymal stromal (stem) cells MMP: Matrix metalloproteinase MRI: Magnetic resonance imaging NC: Notochordal cell NCCM: Notochordal cell conditioned medium NCD: Non-chondrodystrophic NP: Nucleus pulposus NPPC: Nucleus pulposus progenitor cell

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The contributions of the NIH author(s) were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements, and are considered works of the United States Government

In patients who report abnormal findings in previous cystoscopy, if it is unclear to the clinician what the abnormal findings are, cystoscopy may be performed to visualize directly