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[251] found that puerarin (2, 4, and 8 M) may improve LPS-induced inflammation injury in gastric epithelial cells GES-1, and decrease expression of NLR family pyrin domain containing 3 (NLRP3), ASC, cleaved caspase-1, IL-1 and IL-18 by activating AMPK/SIRT1 signaling pathway and inhibiting NLRP3 inflammasoma-mediated apoptosis

Functional toll-like receptor 4 conferring lipopolysaccharide responsiveness is expressed in thyroid cells

However, several RCTs in high-risk people or patients with prostate cancers did not support the benefit of combined supplementation of CoQ 10 , vitamin E, selenium, and vitamin C, along with several phytochemicals [222,223]