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GSH has an important role in detoxification and it can help regenerating some antioxidants such as vita-min C and E, which are also capable of detoxifying hydrogen peroxide [4]

However, it remains unclear how effective they are in diminishing the occurrence of exacerbations and improving quality of life

In addition to its antioxidant activity, glutathione supports immune function by activating T-cells

511,512 Moreover, identifying novel mitophagy receptors or booster of mitophagy further enhances our understanding of the complexity of mitochondrial quality control

However, its precursor TMA has a negative effect on bloodbrain barrier function [247]