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Skin prick tests (SPT) were performed with cyanocobalamin and a possible cross-reaction to the hydroxycobalamin (1mg/ml dilutions)
The lack of significant serum ALT elevation in mice treated with sub-lethal CGA doses (Figure 8C) aligns with the in vitro findings where programmed cell death was predominant
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Recently, three more compounds ( 3d , 22e and 25 ) have been designed based on the C1-27 scaffold (Figure 12GI) [210]
