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All authors OB12 Group read and approved the final manuscript

ARDS has not previously been documented as a response to genomic medicines delivered with this virus and the reaction could not have been predicted

The restoration of spatial learning in APP/PS1 transgenic mice, which develop amyloid plaques and cognitive deficits analogous to human Alzheimer pathology, suggests that massive synaptogenic stimulation can override the connectivity losses caused by amyloid accumulation

Biotechnol J 7:566568

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