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Am J Pathol 2018;188:140618 [DOI] [PMC free article] [PubMed] [Google Scholar] 48.Jaeschke H, Ramachandran A.Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity

Glutathione is an antioxidant that the body naturally produces using three amino acids: glutamine, glycine and cysteine

PXN LOW, low dose paraxanthine

Given the indispensability of NEM or other alkylating agents such as iodoacetamide (IAA) for the accurate analysis of GSH, the majority of recently reported and validated LC-MS-based methods measure the GSH-NEM or GSH-IAA thioethers in parallel with native GSSG (Scheme 3)

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