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Generally, TGF- has been identified as master regulator of immune tolerance, T cell differentiation and mediator of inflammatory responses in multiple cell types (235, 236, 239, 240)

Nei modelli di equivalente dermico, il GHK-Cu a concentrazioni comprese tra 0,1 e 10 M aumentava l'espressione di marcatori delle cellule staminali epidermiche come integrine e p63 nei cheratinociti basali (Pickart & Margolina, OBM Geriatrics 2018)

Nevertheless, chemotherapy-induced DNA damage responses have introduced numerous challenges, such as alterations in DNA damage repair capabilities, which is one of the important factors contributing to the emergence of chemotherapeutic resistance (Huang and Zhou, 2021)

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Increased levels of GSTP1 may be another mechanism regulating cyclin-dependent kinase-5 signaling, eliminating oxidative stress, and preventing neurodegeneration (164)

Moreover, it has been shown that various cytotoxic chemotherapeutic drugs can promote autophagy in cancer cells, often impacting the cell's survival or death [102]