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CpG or GpC methylation of mtDNA downregulates the expression of mitochondrial genes in HepG2 cells Previously, we reported that artificially-induced GpC methylation of the mtDNA repressed expression of certain mitochondrial genes depending on the cell type (17)

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Chamoun K, Benton CB, AlRawi A, Jacamo R, Williams P, Wang F, Zhang J, Daver NG, Garcia-Manero G, Kantarjian HM, Futreal A, Andreeff M

Additionally, DCA has been associated with several side effects (56), highlighting that the clinical application of DCA requires further extensive verification

N-Alkylmorpholines: Potent Dermal and Transdermal Skin Permeation Enhancers Pharmaceutics

Some people find this volume uncomfortable for subcutaneous injection