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And IL-22 has a dual role in UC, which can not only play a protective role by promoting the recovery of the intestinal barrier, but also may exacerbate the inflammatory response by upregulating neutrophil-active chemokines such as Cxcl1

Sheibani N, Jennerwein MM and Eastman A

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But signs and symptoms only tell part of the story

Similarly, substituting with hydroxycholesterol influences cholesterol recognition by NPC1, improving delivery efficiency [236, 237]
10.1016/j.physbeh.2021.113593 78 LiuX.ZhengX.DuG.LiZ.QinX