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A high-fat diet increases intestinal DCA levels, and DCA promotes the expression of HIF- 2 and DMT1, leading to the accumulation of ferrous ions in IECs and the onset of ferroptosis [12]

Messa P, Castellano G, Vettoretti S, et al

Under conditions of increased ROS levels, the production of endogenous L-cysteine (L-Cys) is insufficient for GSH synthesis, which requires the uptake of L-Cys, predominantly in its disulfide form of L-cystine (CSSC), through the xCT transporter, which consists of two subunits: SLC7A11 and SLC3A2 (Figure 3) [102]

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Journal of Infection and Public Health