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Cell 82 , 20842097.e5 (2022)

Additionally, dysregulation in the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway further accentuates the demand for glutamine, driving an accelerated flux through the tricarboxylic acid (TCA) cycle to fuel the biosynthetic requirements of rapidly proliferating cancer cells [31]

Luisi S, Pizzo A, Pinzauti S, Zupi E, Centini G, Lazzeri L, Di Carlo C, Petraglia F

The primary clinical effect of methemoglobin is to reduce the oxygen content of the blood

Peripheral administration of the Class-IIa HDAC inhibitor MC1568 partially protects against nigrostriatal neurodegeneration in the striatal 6-OHDA rat model of Parkinsons disease