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Moderate, dynamic loading (e.g., from walking and appropriate exercise) is essential for maintaining disc cell metabolism, promoting nutrient exchange, and stimulating ECM synthesisthese represent physiological mechanical stimuli (Malandrino et al., 2014

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p53 suppresses the expression of solute carrier family 7 member 11 (SLC7A11), a critical component of the system xc cystine/glutamate antiporter necessary for cystine importation into cells (129)

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R.YazdaniM.ThayyilS.MontaldoP.et al

Fan, Y.-L