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Studies show that B12 deficiency is especially common in pregnant women , vegetarians , older adults , and people with digestive issues or chronic medication use , even in those who feel fine until they suddenly crash

The alteration of TJ homeostasis is thought to induce the pathogenesis of several diseases and vice versa

In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022

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