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Conversely, astrocytic LTF overexpression (that would mostly lack iron) has recently been demonstrated to lower both A and Tau hyperphosphorylation in APP/PS1 mice via targeting the LRP1 receptor, leading to downstream PP2A enzyme activity and ultimately reducing A burden (Fan et al., 2024)

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Biophysical work describes the tetrapeptide binding DNA in the major groove like a small transcription factor and modulating gene expression

[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Bertolino B., Crupi R., Impellizzeri D., Bruschetta G., Cordaro M., Siracusa R., Esposito E., Cuzzocrea S

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