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In addition, the P53-SAT1-ALOX15 pathway is also involved in the regulation of ferroptosis 16

Cellular processes affected by protein glutathionylation include protein folding and stability, nitric oxide regulation, and the activity of cysteinases involved in redox homeostasis

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Results DMF activates the TSS pathway in SCD erythroblasts To investigate the mechanism of DMF on ferroptosis regulation, we conducted untargeted LC-MS using erythroblasts generated from CD34+ stem cells isolated from the peripheral blood of SCD patient