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Medication Overuse Headache Overuse of acute migraine drugs (e.g., ergotamines, triptans, opioids, or a combination of these drugs for 10 or more days per month) may lead to exacerbation of headache (i.e., medication overuse headache)

[3] Subsequent structural optimization introduced the N-terminal tyrosine residue, yielding the compound now designated AOD-9604

Longer storage increases degradation risk

[DOI] [PubMed] [Google Scholar] 6.Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, Stevens VJ, Wadden TA, Wolfe BM, Yanovski SZ G

10.1038/ajg.2012.211 282

BZDs: These agents have the most evidence supporting their efficacy