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There are proven facts that uncontrolled oxidation leads to generate excessive reactive oxygen species (ROS), causative agent of many ailments that can address through antioxidants/phytochemicals rich diets (Butt et al., 2009[20])

Importantly, hepatic gluconeogenesis produces glucose-6-phosphate, which together with that produced from glycogen degradation (glycogenolysis) must be hydrolyzed by glucose-6-phosphatase in the endoplasmic reticulum to be released as glucose into the circulation (Cahill et al., 1959)

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Given the rise in DFU prevalence, along with associated comorbidities and strain on the healthcare system, a plethora of therapies have been investigated in recent years

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