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Annu Rev Med 58:1734 Boelsterli UA (2003) Idiosyncratic drug hepatotoxicity revisited: new insights from mechanistic toxicology

Experimental design After 20 days of growth, tissue culture plantlets were divided into five groups for experimental treatment: (1) T0 (untreated), (2) Cd48 (48 h of growth following the addition of 500 mol/L of CdCl 2 to MS solution), (3) GSH48 (48 h of growth following the addition of 500 mol/L of CdCl 2 and 400 mol/L of GSH to MS solution), (4) Cd96 (96 h of growth following the addition of 500 mol/L of CdCl 2 to MS solution), and (5) GSH96 (96 h of growth following the addition of 500 mol/L of CdCl 2 and 400 mol/L of GSH to MS solution)

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Sterile 0.9% saline: Appropriate where a physiological salt concentration is required by the experimental design

doi:10.1074/jbc.M707733200 Gong P, Cederbaum AI, Nieto N (2003) Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway

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