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The GRK5, a serine/threonine kinase that can regulate G protein-coupled receptor (GPCR) signaling, is the upstream regulator of the HDAC5/Smad3 signal pathway
The relationship between the intron phase and sequence conservation at splice sites is associated with the evolution of spliceosomal introns ( PavGST classes, Subfamilies I, II, III, IV, and V exhibited peak conservation whereas subfamily VI, and VII showed a greater number of introns and mixed conservation at the splice site sequence (Figure 2)
References Vistoli G (2015) CHAPTER 1
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Conditions associated with variant 1298C include fibromyalgia, chronic fatigue, schizophrenia, chronic migraines, and irritable bowel syndrome
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