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This seasonal pattern relates to several factors: Humidity changes: The transition from dry winter air to humid spring conditions Temperature fluctuations: Rapid weather changes stress the skin Allergen exposure: Spring pollens may trigger immune responses Sunlight variations: Changes in UV exposure affect skin biology Interestingly, while summer's heat and humidity might seem like they would worsen SD, the increased UV exposure actually has an anti-inflammatory effect that can improve symptoms

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It achieves this by neutralizing free radicals, thus averting potentially detrimental health conditions

The 16S rRNA stool analysis revealed reduced bacterial diversity and richness, lower anti-inflammatory species, and higher pro-inflammatory species like Enterobacteriaceae in ME/CFS patients [27]

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